MP051GENETIC BACKGROUND DETERMINES MURINE PRIMARY MESANGIAL CELL RESPONSE TO TGF-ß
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چکیده
منابع مشابه
TGF- signal transduction and mesangial cell fibrogenesis
Schnaper, H. William, Tomoko Hayashida, Susan C. Hubchak, and Anne-Christine Poncelet. TGFsignal transduction and mesangial cell fibrogenesis. Am J Physiol Renal Physiol 284: F243–F252, 2003; 10.1152/ajprenal.00300.2002.—Transforming growth factor(TGF) is closely associated with progressive renal fibrosis. Significant progress has been accomplished in determining the cellular signaling pathways...
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Lesions of focal segmental glomerulosclerosis (FSGS) are a pathological hallmark of progressive glomerular injury. Glomerulosclerosis frequently complicates most renal diseases, and is characterized by the collapse of the glomerular tuft with the accumulation of mesangial matrix. Transforming growth factor-ß (TGF-ß) is a key regulator of extracellular matrix (ECM) protein synthesis in renal cel...
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BACKGROUND Thrombosis is the fatal and disabling consequence of cardiovascular diseases, the leading cause of mortality and morbidity in Western countries. Two inbred mouse strains, C57BL/6J and A/J, have marked differences in susceptibility to obesity, atherosclerosis, and vessel remodeling. However, it is unclear how these diverse genetic backgrounds influence pathways known to regulate throm...
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We have previously shown that estradiol suppresses types I and IV collagen synthesis by mesangial cells grown in the presence of serum. In the present study, we examined the interaction between estradiol and transforming growth factor-β (TGF-β) on collagen IV synthesis. In a luciferase reporter gene construct containing the type IV collagen promoter and α1-chain regulatory sequences, we found t...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2017
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfx161.mp051